Peptidic inhibitors of α-Synuclein preventing Parkinson’s disease-associated fibrilization and cytotoxicity
Read here how peptidic inhibitors of α-Synuclein nucleation and fibril elongation can be evaluated on microplate readers.
The PHERAstar® FSX is our most sensitive multi-mode reader for high-throughput screening, combining this sensitivity with fast read times. Thanks to the unique Optic Module system, Simultaneous Dual Emission, UV/vis spectrometer, AAS System, and dedicated AlphaScreen® and TRF lasers, the PHERAstar FSX will perform your assay with ease and speed, even in 3456-well microplates.
No longer worry about installing filters and dichroics: the PHERAstar FSX comes with easy-to-handle, assay-optimized Optic Modules which contain all application-specific filters, mirrors, dichroics and/or polarizers, and are automatically recognised by the plate reader. In addition, the PHERAstar FSX is equipped with four matched and assay-optimized photomultiplier tubes (PMTs) which are automatically selected for the relevant detection mode. You can also measure assays with two emission wavelengths at the same time thanks to the Simultaneous Dual Emission.
For HTS automation purposes, the PHERAstar FSX can be easily integrated into automated systems, and offers improved robotic integration capabilities and multi-user control.
Read here how peptidic inhibitors of α-Synuclein nucleation and fibril elongation can be evaluated on microplate readers.
Snake venom has a very bad image. But it’s not all bad - If you would like to read about the useful functions of snake venoms as an anti-cancer treatment click here.
Looking for alternative acceptor fluorophores in TR-FRET attempts? Read here how CELT-335 was successfully used in a Cannabinoid competition binding assay at CB1.
Read here, how a fluorescence polarization-based interaction assay on the PHERAstar FSX can be used to reduce sample volumes, cost, and time-requirements for high-throughput screening.
Read here, how protein synthesis in cell-free extracts can be used to rapidly screen for protein variants in low-volume single vessel reactions with the CLARIOstar Plus.
Inform yourself here about the benefits of an alternative to (TR-)FRET-/BRET-based competition assays using FP for the determination of kon and koff of ligand/receptor interaction.
Intelligent microplate incubation
Microplate handling system
Low-volume measurements
Filters for a wide range of applications
Functional Microplate Reader Validation