
The PHERAstar FSX masters all these requirements in all detection modes, making it popular in screening facilities. For screening assay development and testing, the CLARIOstar Plus is the perfect addition to develop and characterize an assay before transitioning to high throughput.
Take a look at the links below to find out more about our instruments and how they have been used by drug screeners.
Search our resources section for information about specific applications, literature citations, videos, blog articles and many other publications. Many of the resources provided are associated with current and previous instrument models and versions.
Are you looking for a label-free method to study potential antiviral drugs? This AppNote presents a fast and cheap way to study viral cytopathic effects with cell viability/toxicity assays.
Are you tired of false positive hits affecting your results? In this application note you will find two options for identifying false positive compounds via HTRF measurement.
Are you looking for an easy way to screen for antivirals in 384-well format? This application is ideally suited to investigate virus uptake and replication in living cells.
Did you know, that the 90 min SimpleStep ELISA®s by abcam also work in 384-well format? Read here why our dedicated high-throughput reader PHERAstar® FSX is the perfect match for HTS.
Looking for methods to study the molecular mechanisms of viral replication? In this AppNote a fluorescence-based approach for real-time measurement of viral gene expression is presented.
Studying binding kinetics helps to reduce clinical failure of potential drugs. Read here, how TR-FRET can be used to determine association and dissociation rates of unlabelled compounds.
NanoBRET is used to analyse binding events, signaling pathways and receptor trafficking in live cells and has significantly expanded the range and applications of BRET assays.
Overwhelmed with the abundance of assay options? This blog compares the various advantages and disadvantages of different approaches available for binding assays.
The determination and optimisation of binding affinity are of great importance for the development of new drugs and treatment options. Read more here.
Read here how you can perform Transcreener® assays to e.g. quantify AMP on the powerful and sensitive microplate readers from BMG LABTECH.
The use of monoclonal antibody drugs for therapeutic outcomes remains a topic of high interest throughout the research community. Read more on their history and promises here.
What is high-throughput screening (HTS) and how can it be used? Find out, why BMG LABTECH microplate readers are perfect tools for HTS approaches.
Ghafouri, M;Gauss, CB;Fribley, AM; [2022]
Methods in molecular biology (Clifton, N.J.) 2378 317-327
Baltzer, S;Bulatov, T;Schmied, C;Krämer, A;Berger, BT;Oder, A;Walker-Gray, R;Kuschke, C;Zühlke, K;Eichhorst, J;Lehmann, M;Knapp, S;Weston, J;von Kries, JP;Süssmuth, RD;Klussmann, E; [2022]
International journal of molecular sciences 23(2)
Nguyen, T;Decker, AM;Snyder, RW;Tonetti, EC;Gamage, TF;Zhang, Y; [2022]
European journal of medicinal chemistry 231 114149
Grau-Expósito, J;Perea, D;Suppi, M;Massana, N;Vergara, A;Soler, MJ;Trinite, B;Blanco, J;García-Pérez, J;Alcamí, J;Serrano-Mollar, A;Rosado, J;Falcó, V;Genescà, M;Buzon, MJ; [2022]
PLoS pathogens 18(1) e1010171
Ledala, N;Malik, M;Rezaul, K;Paveglio, S;Provatas, A;Kiel, A;Caimano, M;Zhou, Y;Lindgren, J;Krasulova, K;Illes, P;Dvořák, Z;Kortagere, S;Kienesberger, S;Cosic, A;Pöltl, L;Zechner, EL;Ghosh, S;Mani, S;Radolf, JD;Matson, AP; [2022]
mBio e0375221
Jenkins, L;Marsango, S;Mancini, S;Mahmud, ZA;Morrison, A;McElroy, SP;Bennett, KA;Barnes, M;Tobin, AB;Tikhonova, IG;Milligan, G; [2021]
ACS pharmacology & translational science 4(5) 1598-1613
TRUPATH is a BRET-based platform that enables to monitor discrete GPCR-G protein coupling and can facilitate the discovery of drugs biased towards desired G protein effectors.
Protein-protein interaction is the key in physiological processes - and likewise many diseases. Learn here about possible approaches to study interactions in drug screening using NanoBRET and TR-FRET.
Martin Redhead, group leader at UCB, discusses the use and impact of kinetic binding methods across the drug discovery pipeline.
Watch here, how the PHERAstar’s extraordinary sensitivity allows to detect TR-FRET assays with high reliability and reproducibility even in miniaturized sample volumes using 1536-well plates.
Learn more on successful miniaturization approaches and high-throughput screening attempts in 1536-well plates employing the CRISPR/Cas9 system to knock in Nano luciferase reporter genes.
Leave radioactive assays behind: the PHERAstar provides temporal resolution to determine kon and koff rates by TR-FRET binding kinetics.
David Reed (Managing Director at Flexible Lab Solutions) talks about the seamless integration of the BMG LABTECH microplate reader PHERAstar FSX into this system.
Prof. Heinis´ work focusses on the use of cyclic peptides as drugs. Here he discusses the benefits of this approach and in how the PHERAstar FSX supports his screening needs.
Read in this interview how Martin Redhead from Exscientia searches for optimised drugs and combines AI with human expertise.
Zaida Gloria talks about why she chose the PHERAstar FSX and how this plate reader makes her job easier.
Read in this interview with Steven van Helden,Chief Technology Officer at Pivot Park Screening Centre (PPSC), how you can improve your hit discovery efficiency.
Efficient microplate readers play an important role in effective hit molecule discovery. Mark Wigglesworth, of AstraZeneca, explains what he looks for in this technology.
Powerful and most sensitive HTS plate reader
Most flexible Plate Reader for Assay Development
Microplate nephelometer for light-scattering and turbidity measurements