Cell biology

Discover how cell-based microplate assays advance your research: from viability to cell death mechanisms, from glycolysis to respiration, from lytic assays to live cell assays, from one to multiple assays.

Cell-based studies provide information about basic cellular processes. These include cell division, cell energy balance, control mechanisms, cell death regulation, differentiation or pathology. Cell-based methods are not only used for research: toxicity tests replace animal experiments and identify toxic substances in vitro. In addition, cell cultures have become important production organisms for medicines. For example, they produce insulin or monoclonal antibodies used as cancer therapeutics.

Modern cell biology analyses not only measure at a single time point but monitor biological changes over days in real time. To this end, the measurement chamber of a microplate reader needs controlled temperature and gas conditions. BMG LABTECH´s Atmospheric Control Unit regulates CO2 to stabilize the pH in carbonate buffered cell cultures. Additionally, O2 can be set to physiological conditions, which for mammalian cultures is typically below ambient concentrations. BMG LABTECH microplate readers further correct for non-homogenous distribution of a cell layer as they measure several points across the well instead of only reading in the center. To avoid biased results due to a undetected mycoplasma contamination, BMG LABTECH readers also offer the possibility of detecting existing contamination.

Setting up a cell biology experiment takes time. Therefore, novel assay solutions measure several parameters at once. The combination of different fluorescent, luminescent and chromogenic assays in one well results in multiple readouts. With a flexible microplate reader, all assays can be measured with only one instrument.

A graph that illustrates cell viability

Cell viability and cytotoxicity

Learn about the numerous assays for cell death, toxicity, viability, and metabolic activity ...and how they can all be measured with one microplate reader.
A mycoplasma bacteria

Cell contaminations

Mycoplasma is easily detected by luminescence assays and a BMG LABTECH microplate reader.
Oxidative Stress Diagram

Reactive oxygen species

Whether you are measuring reactive oxygen species in the context of immunology, cancer or ageing, we have the right microplate reader and assay recommendation!
Mitochondrion section

Metabolism

Interested in how your cells produce energy? Then check out how metabolic assays work on our microplate readers.
Cell Membrane structure in motion

Cell membrane

Find out how to measure membrane potential, composition, or fluidity.

Resources

Search our resources section for information about specific applications, literature citations, videos, blog articles and many other publications. Many of the resources provided are associated with current and previous instrument models and versions.

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