Cell signaling

No communication and cellular reactions without signaling molecules

Cells not only receive extracellular cues, they also translate them into intracellular reactions. Extracellular signaling molecules comprise growth factors, hormones, ions, neurotransmitters, cytokines and other molecules such as extracellular ATP as well as proteins such as Sclerostin. Our Microplate readers can readily characterize cytokine, hormone, and second messenger changes and are ideally suited for performing various GPCR applications. They can also be used to study protein modifications like nitration that may also impact signaling.

Cellular reaction time covers from a few seconds to several hours. Accordingly, responses must either be triggered and measured instantly, or they need to be observed in living cells over a longer period of time. BMG LABTECH microplate readers provide injectors and a high sampling rate if fast reactions need to be captured. Further, the Atmospheric Control Unit regulates CO₂ and O₂ levels inside the reading chamber to provide a feel-good atmosphere for long-term cell experiments.

Signaling events rarely come alone, they take place simultaneously or in concert. In order to clearly characterize signaling events, BMG LABTECH multi-mode microplate readers offer the possibility of reading several assays in just one well.