Signaling

No communication and cellular reactions without signaling molecules. Our microplate readers can characterize cytokine, hormone, and second messenger changes.

Cells not only receive extracellular cues, they also translate them into intracellular reactions. Extracellular signaling molecules comprise growth factors, hormones, ions, neurotransmitters, or cytokines.


Cellular reaction time covers from a few seconds to several hours. Accordingly, responses must either be triggered and measured instantly, or they need to be observed in living cells over a longer period of time. BMG LABTECH microplate readers provide injectors and a high sampling rate if fast reactions need to be captured. Further, the Atmospheric Control Unit regulates CO2 and O2 levels inside the reading chamber to provide a feel-good atmosphere for long-term cell experiments.


Signaling events rarely come alone, they take place simultaneously or in concert. In order to clearly characterize signaling events, BMG LABTECH devices offer the possibility of reading several assays in just one well.

Resources

Search our Resources section for information about specific applications, literature citations, videos, blog articles and many other publications. Many of the resources provided are associated with current and previous instrument models and versions.

    • EMRE is essential for mitochondrial calcium uniporter activity in a mouse model

      Liu, JC;Syder, NC;Ghorashi, NS;Willingham, TB;Parks, RJ;Sun, J;Fergusson, MM;Liu, J;Holmström, KM;Menazza, S;Springer, DA;Liu, C;Glancy, B;Finkel, T;Murphy, E;[2020]

      JCI Insight

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    • Comparison of putative BH3 mimetics AT-101, HA14-1, sabutoclax and TW-37 with ABT-737 in platelets

      Wei, H;Harper, MT;[2020]

      Platelets

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    • Acorus gramineusand and Euodia ruticarpa Steam Distilled Essential Oils Exert Anti-Inflammatory Effects Through Decreasing Th1/Th2 and Pro-/Anti-Inflammatory Cytokine Secretion Ratios In Vitro

      Yeh, TH;Lin, JY;[2020]

      Biomolecules

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    • D1-mGlu5 heteromers mediate noncanonical dopamine signaling in Parkinson\'s disease

      Sebastianutto, I;Goyet, E;Andreoli, L;Font-Ingles, J;Moreno-Delgado, D;Bouquier, N;Jahannault-Talignani, C;Moutin, E;Di Menna, L;Maslava, N;Pin, JP;Fagni, L;Nicoletti, F;Ango, F;Cenci, MA;Perroy, J;[2020]

      J. Clin. Invest.

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    • CoCrMo surface modifications affect biocompatibility, adhesion, and inflammation in human osteoblasts

      Lohberger, B;Stuendl, N;Glaenzer, D;Rinner, B;Donohue, N;Lichtenegger, HC;Ploszczanski, L;Leithner, A;[2020]

      Sci Rep

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