Screening

Measuring thousands of wells in minutes, as it is needed for compound screens, requires extremely fast and sensitive instrumentation. Read why BMG LABTECH plate readers are heavily used in screening laboratories.

Drugs acting on a therapeutic target have to be identified out of libraries of thousands to millions of compounds. Due to the large amount of tests necessary for a screen, they are mainly conducted in 384 and 1536 well plates to minimize reaction volumes per sample.


Speed and sensitivity are key requirements for high-throughput screening microplate readers. A 1536 well microplate needs to be measured in seconds, maximally a few minutes. Furthermore, the fast measurement of 10 µl or even lower volume samples need to be very precise and stable to clearly identify hits from a vast number of compounds. In addition, the reader needs to be reliable, as errors occurring during a screen result in repetitions, loss of time, reagents and consequently money. The PHERAstar FSX masters all these requirements in all detection modes, making it popular in screening facilities.


For screening assay development and testing, it is not necessary to block the dedicated screening reader, the CLARIOstar Plus is the perfect addition to develop and characterize an assay before transitioning to high throughput.

Resources

Search our Resources section for information about specific applications, literature citations, videos, blog articles and many other publications. Many of the resources provided are associated with current and previous instrument models and versions.

    • The identification and characterisation of autophagy inhibitors from the published kinase inhibitor sets

      Zachari, M;Rainard, JM;Pandarakalam, GC;Robinson, L;Gillespie, J;Rajamanickam, M;Hamon, V;Morrison, A;Ganley, IG;McElroy, SP;[2020]

      Biochem. J.

      Read article
    • Discovery of 1,6-naphthyridinone-based MET kinase inhibitor bearing quinoline moiety as promising antitumor drug candidate

      Chen, T;Zhuo, LS;Liu, PF;Fang, WR;Li, YM;Huang, W;[2020]

      Eur J Med Chem

      Read article
    • Signalling profiles of a structurally diverse panel of synthetic cannabinoid receptor agonists

      Patel, M;Manning, JJ;Finlay, DB;Javitch, JA;Banister, SD;Grimsey, NL;Glass, M;[2020]

      Biochem. Pharmacol.

      Read article
    • D1-mGlu5 heteromers mediate noncanonical dopamine signaling in Parkinson\'s disease

      Sebastianutto, I;Goyet, E;Andreoli, L;Font-Ingles, J;Moreno-Delgado, D;Bouquier, N;Jahannault-Talignani, C;Moutin, E;Di Menna, L;Maslava, N;Pin, JP;Fagni, L;Nicoletti, F;Ango, F;Cenci, MA;Perroy, J;[2020]

      J. Clin. Invest.

      Read article
    • CRISPR-Mediated Protein Tagging with Nanoluciferase to Investigate Native Chemokine Receptor Function and Conformational Changes

      White, CW;Caspar, B;Vanyai, HK;Pfleger, KDG;Hill, SJ;[2020]

      Cell Chem Biol

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