DNA quantification
Read how various nucleic acid quantification methods, ranging from UV absorbance and fluorescent dyes to amplification methods, can be performed on BMG LABTECH microplate readers.
One such enzyme family is the Histone Deacetylases (HDACs), which modify histones and which in turn helps to regulate gene transcription. Though the mechanism of action is not fully known, it has been shown that inhibition of HDACs results in the overacetylation of histones that in turn can lead to a controlled cell death or apoptosis. As such, several HDAC inhibitors (HDIs) are in phase I or II clinical trials, for example suberoylanilide hydroxamic acid (SAHA; ZOLINZA®, Merck).
Check out one of our application notes that describes an HDAC assay (fig.1): A Fluorescence Based Assay of the Epigenetic Enzyme Histonedeacetylase 1 (HDAC1).
