Biochemistry

The complexity of life is based on chemical processes within organisms. Biochemistry studies these chemical reactions and our readers are the tools for your discoveries.

Methods that answer biochemical question are as varied as the chemical processes in living organisms. They cover simple protein quantification assays such as Bradford or Lowry assay to adjust protein extracts for further analysis, as well as enzyme activity assays helping to find inhibitory and accelerating conditions. These assays benefit from BMG LABTECH´s kinetic read options, an Enhanced Dynamic Range for high intensity variations in a measurement and a suite of enzyme kinetic analysis options.


An achievement of the past 20 years has been the multitude of protein interaction assays that can be carried out in 96 to 1536 well plates. They replace lengthy or radioactive procedures and facilitate the screening for potential active substances.


BMG LABTECH microplate readers measure all these assays. They not only provide highest sensitivity and throughput, if necessary, they further assist in developing your own assays and adapting existing methods to your specific target.

Resources

Search our Resources section for information about specific applications, literature citations, videos, blog articles and many other publications. Many of the resources provided are associated with current and previous instrument models and versions.

    Binding Affinity
    April 26, 2021

    How to determine binding affinity with a microplate reader?

    Many biological processes are driven by the interaction of two molecules. Enzymatic reactions, protein protein binding, DNA replication or receptor-ligand interactions are just a few examples which inevitably depend on the close proximity of two binding partners and their binding affinity to each other. To induce their effect, drugs are often specifically designed to target molecular interactions associated with specific diseases. Accordingly, in the fields of pharmaceutical research, and drug discovery, the determination and optimisation of binding affinity are of great importance for the development of new drugs and treatment options. 

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    Neurodegenerative disease research
    April 02, 2020

    Neurodegenerative disease research

    Today, life expectancy in developed countries is well above 80 years of age, but with a longer life expectancy comes a higher chance of developing a neurodegenerative disease, such as Alzheimer’s disease, Parkinson’s disease and dementia. As these disorders progress, they become increasingly debilitating until full-time care is required. Unfortunately, the etiology of these diseases is still not fully understood, and most drugs only treat symptoms. With life expectancy on the rise, it is important to further our understanding of these conditions and develop new treatments. 

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    • Washingtonia filifera seed extracts inhibit the islet amyloid polypeptide fibrils formations and α-amylase and α-glucosidase activity

      Floris, S;Fais, A;Medda, R;Pintus, F;Piras, A;Kumar, A;Kuś, PM;Westermark, GT;Era, B;[2021]

      Journal of enzyme inhibition and medicinal chemistry

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    • Inhibition of bacterial and human zinc-metalloproteases by bisphosphonate- and catechol-containing compounds

      Rahman, F;Nguyen, TM;Adekoya, OA;Campestre, C;Tortorella, P;Sylte, I;Winberg, JO;[2021]

      Journal of enzyme inhibition and medicinal chemistry

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    • A glycoengineered antigen exploiting a conserved protein O-glycosylation pathway in the Burkholderia genus for detection of glanders infections

      Wang, G;Glaser, L;Scott, NE;Fathy Mohamed, Y;Ingram, R;Laroucau, K;Valvano, MA;[2021]

      Virulence

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    • Brazilin Removes Toxic Alpha-Synuclein and Seeding Competent Assemblies from Parkinson Brain by Altering Conformational Equilibrium

      Nahass, GR;Sun, Y;Xu, Y;Batchelor, M;Reilly, M;Benilova, I;Kedia, N;Spehar, K;Sobott, F;Sessions, RB;Caughey, B;Radford, SE;Jat, PS;Collinge, J;Bieschke, J;[2021]

      Journal of molecular biology

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    • Epithelia-sensory neuron crosstalk underlies cholestatic itch induced by lysophosphatidylcholine

      Chen, Y;Wang, Z;Yeo, M;Zhang, Q;López-Romero, A;Ding, H;Zhang, X;Zeng, Q;Morales-Lázaro, S;Moore, C;Jin, Y;Yang, H;Morstein, J;Bortsov, A;Krawczyk, M;Lammert, F;Abdelmalek, M;Diehl, A;Milkiewicz, P;Kremer, A;Zhang, J;Nackley, A;Reeves, T;Ko, M;Ji, R;Rosen[2021]

      Gastroenterology

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