Aggregation of misfolded proteins leads to diseases like Parkinson’s, Alzheimer’s or prion disease. We have the dedicated reader for aggregation assays.
Methods that answer biochemical question are as varied as the chemical processes in living organisms. They cover simple protein quantification assays such as Bradford or Lowry assay to adjust protein extracts for further analysis, as well as enzyme activity assays helping to find inhibitory and accelerating conditions. These assays benefit from BMG LABTECH´s kinetic read options, an Enhanced Dynamic Range for high intensity variations in a measurement and a suite of enzyme kinetic analysis options.
An achievement of the past 20 years has been the multitude of protein interaction assays that can be carried out in 96 to 1536 well plates. They replace lengthy or radioactive procedures and facilitate the screening for potential active substances.
BMG LABTECH microplate readers measure all these assays. They not only provide highest sensitivity and throughput, if necessary, they further assist in developing your own assays and adapting existing methods to your specific target.
Search our Resources section for information about specific applications, literature citations, videos, blog articles and many other publications. Many of the resources provided are associated with current and previous instrument models and versions.
Fast and accurate detection of Alzheimer’s Disease targets with SimpleStep ELISA kits and SPECTROstar NanoMallori Milligan (1) , Scott Detmer (1) , Carl Peters (2), (1) Abcam, Cambridge, UK , (2) BMG LABTECH, Cary, NC, 08/2020
Immuno-oncology biomarker measurement with high sensitivity and speed using SimpleStep ELISA kits and SPECTROstar NanoMallori Milligan (1) , Scott Detmer (1) , Carl Peters (2), (1) Abcam, Cambridge, UK , (2) BMG LABTECH, Cary, NC, 06/2020
Binding kinetics: high throughput assay for kinase inhibitorsKrumm A (1) , Georgi V (2) , Schiele F (2) , Fernández-Montalván A (2), (1) BMG LABTECH GmbH , (2) Bayer AG, Drug Discovery, Pharmaceuticals, Berlin, Germany, 06/2020
Ubiquitination monitoring in real-time: the ﬂuorescence polarization-based method UbiRealTyler G. Franklin , Jonathan N. Pruneda, Oregon Health & Science University, Dept. of Molecular Microbiology and Immunology, Portland, OR, USA, 05/2020
Elucidating PROTAC MoA with live cell kinetic monitoring of ternary complex formation and target protein ubiquitinationKristin Riching , Amy Landreman , Danette Daniels, Promega, Madison, WI, U.S.A, 04/2020
Optimizing your ELISA Assays
Monoclonal antibody drugs – a history of success and a bright future!
Protein measurement: find a suitable method
The absorbance spectrum of hemoglobin
β-Turn mimetic synthetic peptides as amyloid-β aggregation inhibitorsRead article
Kinetic Analysis of the Early Signaling Steps of the Human Chemokine Receptor CXCR4Read article
USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylationRead article
Life Sci Alliance
Anti-tumor effects of mevalonate pathway inhibition in ovarian cancerRead article
Papain-like protease regulates SARS-CoV-2 viral spread and innate immunityRead article