
In the past, cell-based assays required the use of expensive HTS equipment, which lead to limited accessibility for scientists in the assay development stage. In order to reduce this bottleneck, BMG LABTECH developed the NOVOstar, an exciting microplate reader for screening a large number of compounds in fast kinetic, cell-based assays and research development. The NOVOstar is a compact microplate reader offering five detection modes in a unique combination with an integrated pipettor system for automated assembly and instantaneous reading of assays in microplate formats up to 384-well.
Exceptional Technologies The NOVOstar has numerous features that cannot be found on other microplate readers including:
Software The NOVOstar multidetection microplate reader comes with BMG LABTECH's established reader control software and powerful MARS data analysis software. It is compatible with the Windows XP / Vista / 7 operating system, offers an extended ASCII data export function and is fully compliant with FDA regulation 21 CFR Part 11. The familiar and highly visual reader control software allows flexible definition of microplate layouts, filter selection, interval and injection times, as well as measurement frequency, heating, and shaking parameters. During measurement, it is possible to observe the data with the current state view, which allows viewing of raw values, ratios, curves, or even color coded pictorials in real time. The comprehensive Data Analysis Software - MARS - offers a template manager for building complex data processing protocols and a wizard-guided interface to create easy step-by-step calculations. New features include powerful sort and order functionality; averaging of raw and blank corrected data, lock on data trace, automated or user-defined range adjustment, zoom functions, and a curve fitting library to allow fast calculation of EC50, IC50, r2, and CV values. In order to run BMG LABTECH microplate readers, you also need a personal computer with WindowsTM operating system (7/Vista/Win 2000/XP). Easy export to MS ExcelTM 2007/2003/2000/XP is possible.
NOVOstar applications include:
Due to the integrated pipettor system, the NOVOstar is especially well-suited to screen large numbers of compounds in kinetic cell-based assays or to create a dose response curve by measuring a wide range of analyte concentrations. For BMG LABTECH application notes that can be performed on the NOVOstar, please click here. | |||||||||||||||||
| Detection Modes | Fluorescence Intensity - including FRET Fluorescence Polarization / Anisotropy Luminescence (flash and glow) Time-Resolved Fluorescence - including DELFIA® UV/Vis absorbance |
| Measurement Modes | Top and bottom reading Endpoint and Kinetic measurements Sequential Multi Excitation measurements Sequential Multi Emission measurements Simultaneous Dual Emission measurements Ratiometric measurements |
| Certified for | DLReady™ |
| Microplate Formats | 6 to 384-well plates, user-definable |
| Microplate Carrier | Dual: one reagent plate and one measurement plate |
| Light Sources | High energy xenon flash lamp |
| Detectors | Low noise photomultiplier tube |
| Wavelength Selection | Optical Filters: Ex and Em wheels for 8 filters each |
| Optical Filters | Excitation and emission filter wheels for 8 filters each |
| Optical Path Guides | Top: Liquid filled light guides Bottom: Fiber optics |
| Spectral Range | 240 - 750 nm or 240 - 900 nm for ABS, FI, FP, FRET, TRF, TR-FRET 240 - 750 nm for LUM |
| Sensitivity* | FI < 50pM (< 1 fmol/well Fluorescein, 384sv, 20 μL) FP < 5 mP SD at 1 nM Fluorescein, 96, 200 μL TRF < 3.5 pM (< 70 amol/well Europium, 384sv, 20 μL) LUM < 1.5 pM (< 30 amol/well ATP, 384sv, 20 μL) ABS Dynamic range: ±0.000 - 4.000 OD Reproducibility: ±0.010 OD for 0 - 2 OD range |
| Read Times | Flying mode 14 s (96), 27 s (384) |
| Reagent Injection | Up to 2 built-in reagent injectors Injection at measurement position (6 to 384-well) Individual injection volumes for each well (3 to 350 µL) Variable injection speed up to 420 µL / s Up to four injection events per well Reagent back flushing |
| Pipettor System | Injection volume: 0.5 µL - 100 µL Individual injection volumes for each well Variable injection speed Plate-to-plate transfer + 3 reagent stations + washing station |
| Shaking | Linear, orbital, and double-orbital with user-definable time and speed |
| Purge Gas Vent | System to inject an atmosphere or to pull a vacuum into the reader |
| Incubation | +5°C above ambient up to 45°C or 60°C |
| Software | Multi-user Reader Control and MARS Data Analysis Software included, FDA 21 CFR Part 11 compliant |
| Dimensions | Width: 78 cm, depth: 53 cm, height: 30 cm; weight: 55 kg |
| Accessories | Optional Accessories |
| THERMOstar | Microplate Incubator and Shaker |
| Optical Filters | Optimized for dyes, fluorophores and specific assays Filters for all applications from UV to NIR Customized filters available upon request |
| Upgrades | Upgrades to include options such as additional detection modes, reagent injectors, etc. are available. Please contact your local representative for more information. |
| * | LOD = 3 x SD (20 blanks) / slope (6 pt std curve) Microplatets: white for LUM, TRF; black for FI, FP; clear for ABS 96 = 96-well microplates 384sv = 384-well small volume microplates 384g = 384-well glass bottom microplates |
Not all of the features mentioned above are available in the basic units or in all detection modes. Optional accessories may be necessary to perform certain assays. Please contact your local distributor for details.
Click on the readers below to choose the instruments that you would like to compare to the NOVOstar. Then press "Go" to start the comparison.
Please note that the order in which you click the products will be the order in which the products are shown.
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