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Multi-mode microplate readers are capable of operating in two or more detection modes. Typically, they combine an absorbance plate reader, a luminescence plate reader, and a fluorescence plate reader. In addition, the range can be enhanced with more advanced detection modes like TRF, TR-FRET, fluorescence polarization and AlphaScreen/AlphaLISA.

An absorbance microplate reader detects the light photons absorbed by a sample present in a microplate, when exposed to light at a specific wavelength. Compared to a spectrophotometer that measures one sample at a time in a cuvette, an absorbance microplate reader can measure the same assay in higher throughput.

A fluorescence plate reader detects the light emitted by a fluorescent sample present in a microplate upon excitation with light at a specific wavelength. Fluorescence plate readers are used for fluorescence intensity and FRET detection and are available as single- or multi-mode readers, when combined with absorbance and/or luminescence.

A luminescence microplate reader detects the light emitted by chemical, bio-chemical or enzymatic reactions. Luminescence plate readers are used for flash, glow assays and BRET detection and are available as single- or multi-mode readers, when combined with absorbance and/or fluorescence.

A nephelometer microplate reader is an instrument dedicated to the measurement of the turbidity of a sample, usually caused by the presence of insoluble particles suspended in a liquid. Nephelometer microplate readers measure the light scattering generated by these particles and are used for solubility or aggregation studies.