Molecular biology

Our microplate readers answer your questions on nucleic acids: concentration, interaction with other nucleic acids or proteins, single nucleotide polymorphisms and expression of genes.

Molecular biology deals with biomolecules, their structure, function, and interactions. Since the discovery and description of DNA in the 1950s, we came to understand how DNA gets first transcribed into RNA and then translated into proteins. We further understand that the genome is not the only basis for a cell’s behavior, differentiation, and pathology. Epigenetic regulation, transcription regulation and non-coding RNAs are just as important.


Today, microplate reader assays are well-established tools to answer the questions that are still open. Luminescent reporter assays study gene regulation, interaction assays examine binding of nucleic acids to proteins and enzyme activity assays report on activities of polymerases or helicases.

 

Genomics is a multidisciplinary and essential part of modern biology.  Next generation sequencing (NGS) and SNP-genotyping are popular tools. The field is also closely associated with transcription and translation, investigating proteins and expression levels, both to directly inform studies but also as part of analysis workflows such as NGS.


Microplate reader also take measurements in preparation for PCRs and sequencing. They quantify nucleic acids in high throughput (96-1536 wells), e.g. with NextGenPCRTM, and determine nucleic acid purity via absorbance spectra.

 

BMG LABTECH microplate readers offer solutions from simple quantification devices able to quantify DNA, RNA and protein efficiently and in high throughput, up to multi-functional devices suitable for all needs: reporter assays, binding assays, enzyme assays, evaluation of transfection efficiency, no matter which detection mode.

Resources

Search our Resources section for information about specific applications, literature citations, videos, blog articles and many other publications. Many of the resources provided are associated with current and previous instrument models and versions.

    • Inhibin Inactivation in Female Mice Leads to Elevated FSH Levels, Ovarian Overstimulation, and Pregnancy Loss

      Walton, KL;Goney, MP;Peppas, Z;Stringer, JM;Winship, A;Hutt, K;Goodchild, G;Maskey, S;Chan, KL;Brûlé, E;Bernard, DJ;Stocker, WA;Harrison, CA;[2022]

      Endocrinology

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    • 2021

      5005061[0]

      Aqueous extracts of lingonberry and blackberry leaves identified by high-content screening beneficially act on cholesterol metabolism

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    • 2021

      5004995[0]

      Lrp6 Genotype affects Individual Susceptibility to Nonalcoholic Fatty Liver Disease and Silibinin Therapeutic Response via Wnt/β-catenin-Cyp2e1 Signaling

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    • MiR-509-3p is oncogenic, targets the tumor suppressor PHLPP2, and functions as a novel tumor adjacent normal tissue based prognostic biomarker in colorectal cancer

      Iyer, DN;Foo, DC;Lo, OS;Wan, TM;Li, X;Sin, RW;Pang, RW;Law, WL;Ng, L;[2022]

      BMC cancer

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    • A Versatile Transcription Factor Biosensor System Responsive to Multiple Aromatic and Indole Inducers

      Nasr, MA;Timmins, LR;Martin, VJJ;Kwan, DH;[2022]

      ACS synthetic biology

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