Molecular biology

Our microplate readers answer your questions on nucleic acids: concentration, interaction with other nucleic acids or proteins, single nucleotide polymorphisms and expression of genes.

Molecular biology deals with biomolecules, their structure, function, and interactions. Since the discovery and description of DNA in the 1950s, we came to understand how DNA gets first transcribed into RNA and then translated into proteins. We further understand that the genome is not the only basis for a cell’s behavior, differentiation, and pathology. Epigenetic regulation, transcription regulation and non-coding RNAs are just as important.


Today, microplate reader assays are well-established tools to answer the questions that are still open. Luminescent reporter assays study gene regulation, interaction assays examine binding of nucleic acids to proteins and enzyme activity assays report on activities of polymerases or helicases.


In addition to answering molecular biology questions, the reader also takes measurements in preparation for PCRs and sequencing. It quantifies nucleic acids in high throughput (96-1536 wells) and determines their purity via absorbance spectra.


BMG LABTECH microplate readers offer solutions from simple quantification devices with high-throughput and automation capabilities, up to multi-functional devices suitable for all needs: reporter assays, binding assays, enzyme assays, no matter which detection mode.

Resources

Search our Resources section for information about specific applications, literature citations, videos, blog articles and many other publications. Many of the resources provided are associated with current and previous instrument models and versions.

    • The association of megalin and cubilin genetic variants with serum levels of 25-hydroxvitamin D and the incidence of acute coronary syndrome in Egyptians: A case control study

      Elsabbagh, RA;Abdel Rahman, MF;Hassanein, SI;Hanafi, RS;Assal, RA;Shaban, GM;Gad, MZ;[2020]

      J Adv Res

      Read article
    • TP53 mutations in head and neck cancer cells determine the Warburg phenotypic switch creating metabolic vulnerabilities and therapeutic opportunities for stratified therapies

      Wilkie, MD;Anaam, EA;Lau, AS;Rubbi, CP;Jones, TM;Boyd, MT;Vlatković, N;[2020]

      Cancer Lett.

      Read article
    • Tendentious effects of automated and manual metagenomic DNA purification protocols on broiler gut microbiome taxonomic profiling

      Fidler, G;Tolnai, E;Stagel, A;Remenyik, J;Stundl, L;Gal, F;Biro, S;Paholcsek, M;[2020]

      Sci Rep

      Read article
    • Linagliptin and telmisartan induced effects on renal and urinary exosomal miRNA expression in rats with 5/6 nephrectomy

      Delić, D;Wiech, F;Urquhart, R;Gabrielyan, O;Rieber, K;Rolser, M;Tsuprykov, O;Hasan, AA;Krämer, BK;Baum, P;Köhler, A;Gantner, F;Mark, M;Hocher, B;Klein, T;[2020]

      Sci Rep

      Read article
    • Streptococcus pneumoniae Nasopharyngeal Carriage among PCV-10-Vaccinated HIV-1-Infected Children with Maintained Serological Memory in Ethiopia

      Lemma, M;Bekele, Y;Petkov, S;Hägglund, M;Petros, B;Aseffa, A;Howe, R;Chiodi, F;[2020]

      Pathogens

      Read article