Microplate Reader Software

Ready to run with predefined protocols

The Reader Control comes with more than 30 predefined detection protocols already installed, enabling quick and easy access to the most commonly used applications. Existing protocols can be modified, or new protocols can be created, depending on the user´s needs.

Predefined protocols include DNA/RNA concentration, protein concentration (Lowry, Bradford, BCA), ELISAs, cell growth, NADH/NAD+ conversion, DLRTM, ADP-Glo®, LanthaScreen®, HTRF® cAMP and IP-One, LANCE®, AlphaScreen®, AlphaLISA®, Transcreener®, calcium assays (FLuo3/4/8), GeneBLAzer®, PathHunter®, Picogreen®, GFP, and CFP-YFP.

Full flexibility for complex tasks

The Reader Control supports endpoint and kinetic detection, sequential and simultaneous multi-detection, spectral scanning and multiple well scanning modes. In addition, it controls reagent injectors, gas (O₂ and CO₂) and temperature, as well as shaking. A script wizard allows for the multiplexing of different measurement protocols and more complex operations.

Comprehensive data analysis package

MARS is designed to make microplate reader data analysis simple and effective by displaying, extracting, and exporting information to make data reduction as effortless as possible.

Determine sample concentrations with ease

Whether interpolating a standard curve to get unknown sample concentrations or modelling a biological system, MARS offers various fit and interpolation models including polynomial, 4P- / 5P or user-defined fit models. Curve interpolation and fitting is simplified by MARS’ unique curve fit wizard.

Automate your analysis workflows 

To simplify data reduction after measurement, complex and assay-specific analyses and calculations can be created and saved in MARS as calculation templates. Templates can be linked to specific detection protocols, enabling data generation and analysis with just two mouse clicks. Templates can be exported to be shared with other MARS users and guarantee analysis and result conformity.

Well mapping to check for sample homogeneity

Insoluble particles like cells or aggregates typically do not evenly distribute across the well. Matrix scanning, a key feature on BMG LABTECH readers, scans a whole well creating a matrix with up to 900 points/well resolution. In MARS, the different data points can be analysed separately or as clusters. Data can also be displayed as a 3D well map. This feature can also be used to view kinetic absorbance data three dimensionally.

Enzymatic analysis made easy 

MARS can instantly analyse enzyme activity data to determine enzymatic constants such as K_m and V_max by fitting to various models like Michaelis-Menten, Lineweaver-Burk, Eadie-Hofstee, Hanes-Woolf and Scatchard plot. This software feature, when used in conjunction with BMG LABTECH's high speed UV/vis spectrometer, will revolutionize microplate based enzyme kinetics.

Advanced fittings for binding assays 

Binding kinetics as equilibrium or real-time interaction assays require advanced curve fitting capabilities and models. MARS offers various fit models including models for association, dissociation and competitive inhibition assays that are often used for compound screening of even low-affinity compounds. 

Parallel-line and dose-response curve analysis

Compare different drugs based on their EC₅₀ / EC_X values or estimate their relative potency using MARS’ ‘Parallel-line Analysis’ and ‘Standard Curve Calculation’ feature. The ‘Parallel-line Analysis’ feature offers global fitting followed by ANOVA-like analysis and equivalence testing (suggested by the US Pharmacopeia) to test for bioequivalence. MARS offers different fit models including linear, 4P- and 5P-models. Even more fit models are available with MARS’ ‘Standard Curve Calculation’ feature