Using the SPECTROstar Nano to further evaluate the effects of ssDNA, dsDNA and oligonucleotides

January 05, 2012

Andrey Komissarov of The University of Texas Health Science Center at Tyler, USA was one of the runner' s up in BMG LABTECH's SPECTROstar Nano competition with his proposal: Evaluation of effects of DNA templates on the reaction of urokinase (uPA) and tissue plasminogen activator (tPA) with plasminogen

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Dr EJ Dell
PhD, Sales Manager Northwest

In this proposal, these researchers would like to use the SPECTROstar Nano optical absorbance plate reader for further evaluation of the effects of ssDNA, dsDNA and oligonucleotides on the activation of plasminogen (PLG) by tissue (tPA) and urokinase plasminogen (uPA). The major goals of this project include characterizing the template mechanism of DNA-assisted PLG activation by tPA and uPA and then developing a micro assay for measuring the rates of PLG activation using the SPECTROstar Nano and the low volume LVis plate. The researchers conclude, “…this proposal would benefit not only the fields of molecular mechanisms of fibrinolysis, PLG activation and fibrinolytic therapy, but also give a rigorous field test of this novel product.”

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