Studying the blood brain barrier
Oxygen and hormones were allowed to enter the brain, but larger molecules such as drug compounds, bacteria and even antibodies cannot pass the blood brain barrier. The tight junctions between the epithelial cells was one of the main causes that restricted passage into the brain. It has also been shown recently that there is a P-glycoprotein pump that actively pushes any molecules, including cancer drugs, out of the brain. To help study the blood brain barrier, the Fluorosome Company has created a simple, rapid, non-cellular assay that rivals the classic Caco-2 assay to study these PGP pumps.