Studying the blood brain barrier

October 06, 2011

The blood brain barrier was always thought to be an impenetrable wall of epithelial cells that did not allow molecules of a certain size to pass.

Image of Dr EJ Dell
Dr. EJ Dell
PhD, Sales Manager Northwest
BMG LABTECH USA

Oxygen and hormones were allowed to enter the brain, but larger molecules such as drug compounds, bacteria and even antibodies cannot pass the blood brain barrier. The tight junctions between the epithelial cells was one of the main causes that restricted passage into the brain. It has also been shown recently that there is a P-glycoprotein pump that actively pushes any molecules, including cancer drugs, out of the brain. To help study the blood brain barrier, the Fluorosome Company has created a simple, rapid, non-cellular assay that rivals the classic Caco-2 assay to study these PGP pumps.

 

Further information:

AN 208: A fast and simple method for measuring P-glycoportein (Pgp) inhibition

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