Measuring thousands of wells in minutes, as it is needed for compound screens, requires extremely fast and sensitive instrumentation. Read why BMG LABTECH plate readers are heavily used in screening laboratories.

Drugs acting on a therapeutic target have to be identified out of libraries of thousands to millions of compounds. Due to the large amount of tests necessary for a screen, they are mainly conducted in 384 and 1536 well plates to minimize reaction volumes per sample.

Speed and sensitivity are key requirements for high-throughput screening microplate readers. A 1536 well microplate needs to be measured in seconds, maximally a few minutes. Furthermore, the fast measurement of 10 µl or even lower volume samples need to be very precise and stable to clearly identify hits from a vast number of compounds. In addition, the reader needs to be reliable, as errors occurring during a screen result in repetitions, loss of time, reagents and consequently money. The PHERAstar FSX masters all these requirements in all detection modes, making it popular in screening facilities.

For screening assay development and testing, it is not necessary to block the dedicated screening reader, the CLARIOstar Plus is the perfect addition to develop and characterize an assay before transitioning to high throughput.


Search our Resources section for information about specific applications, literature citations, videos, blog articles and many other publications. Many of the resources provided are associated with current and previous instrument models and versions.

    • Binding pathway determines norepinephrine selectivity for the human β1AR over β2AR

      Xu, X;Kaindl, J;Clark, MJ;Hübner, H;Hirata, K;Sunahara, RK;Gmeiner, P;Kobilka, BK;Liu, X;[2020]

      Cell Res

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    • Discovery and Characterization of BAY 1214784, an Orally Available Spiroindoline Derivative Acting as a Potent and Selective Antagonist of the Human Gonadotropin-Releasing Hormone Receptor as Proven in a First-In-Human Study in Postmenopausal Women

      Panknin, O;Wagenfeld, A;Bone, W;Bender, E;Nowak-Reppel, K;Fernández-Montalván, AE;Nubbemeyer, R;Bäurle, S;Ring, S;Schmees, N;Prien, O;Schäfer, M;Friedrich, C;Zollner, TM;Steinmeyer, A;Mueller, T;Langer, G;[2020]

      J Med Chem

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    • Structure of the human gonadotropin-releasing hormone receptor GnRH1R reveals an unusual ligand binding mode

      Yan, W;Cheng, L;Wang, W;Wu, C;Yang, X;Du, X;Ma, L;Qi, S;Wei, Y;Lu, Z;Yang, S;Shao, Z;[2020]

      Nat Commun

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    • The Sensing Liver: Localization and Ligands for Hepatic Murine Olfactory and Taste Receptors

      Kurtz, R;Steinberg, LG;Betcher, M;Fowler, D;Shepard, BD;[2020]

      Front Physiol

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    • Decreased striatal adenosine A2A-dopamine D2 receptor heteromerization in schizophrenia

      Valle-León, M;Callado, LF;Aso, E;Cajiao-Manrique, MM;Sahlholm, K;López-Cano, M;Soler, C;Altafaj, X;Watanabe, M;Ferré, S;Fernández-Dueñas, V;Menchón, JM;Ciruela, F;[2020]


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