Molecular biology

Our microplate readers answer your questions on nucleic acids: concentration, interaction with other nucleic acids or proteins, single nucleotide polymorphisms and expression of genes.

Molecular biology deals with biomolecules, their structure, function, and interactions. Since the discovery and description of DNA in the 1950s, we came to understand how DNA gets first transcribed into RNA and then translated into proteins. We further understand that the genome is not the only basis for a cell’s behavior, differentiation, and pathology. Epigenetic regulation, transcription regulation and non-coding RNAs are just as important.


Today, microplate reader assays are well-established tools to answer the questions that are still open. Luminescent reporter assays study gene regulation, interaction assays examine binding of nucleic acids to proteins and enzyme activity assays report on activities of polymerases or helicases.


In addition to answering molecular biology questions, the reader also takes measurements in preparation for PCRs and sequencing. It quantifies nucleic acids in high throughput (96-1536 wells) and determines their purity via absorbance spectra.


BMG LABTECH microplate readers offer solutions from simple quantification devices with high-throughput and automation capabilities, up to multi-functional devices suitable for all needs: reporter assays, binding assays, enzyme assays, no matter which detection mode.

Resources

Search our Resources section for information about specific applications, literature citations, videos, blog articles and many other publications. Many of the resources provided are associated with current and previous instrument models and versions.

    • Pyrazinamide resistance and pncA mutations in drug resistant Mycobacterium tuberculosis clinical isolates from Myanmar

      Ei, P;Mon, A;Htwe, M;Win, S;Aye, K;San, L;Zaw, N;Nyunt, W;Myint, Z;Lee, J;Aung, W;[2020]

      Tuberculosis

      Read article
    • Identification of a juvenile-hormone signaling inhibitor via high-throughput screening of a chemical library

      Kayukawa, T;Furuta, K;Nagamine, K;Shinoda, T;Yonesu, K;Okabe, T;[2020]

      Sci Rep

      Read article
    • Bipolar electroactive conducting polymers for wireless cell stimulation

      Qin, C;Yue, Z;Chao, Y;Forster, R;Maolmhuaidh, F;Huang, X;Beirne, S;Wallace, G;Chen, J;[2020]

      Applied Materials Today

      Read article
    • Mutations in COPA lead to abnormal trafficking of STING to the Golgi and interferon signaling

      Lepelley, A;Martin-Niclós, MJ;Le Bihan, M;Marsh, JA;Uggenti, C;Rice, GI;Bondet, V;Duffy, D;Hertzog, J;Rehwinkel, J;Amselem, S;Boulisfane-El Khalifi, S;Brennan, M;Carter, E;Chatenoud, L;Chhun, S;Coulomb l'Hermine, A;Depp, M;Legendre, M;Mackenzie, KJ;Marey,[2020]

      J. Exp. Med.

      Read article
    • mTOR-dependent translation amplifies microglia priming in aging mice

      Keane, L;Antignano, I;Riechers, SP;Zollinger, R;Dumas, AA;Offermann, N;Bernis, ME;Russ, J;Graelmann, FJ;McCormick, PN;Esser, J;Tejera, D;Nagano, A;Wang, J;Chelala, C;Biederbick, Y;Halle, A;Salomoni, P;Heneka, MT;Capasso, M;[2020]

      J Clin Invest

      Read article