Signaling

No communication and cellular reactions without signaling molecules. Our microplate readers can characterize cytokine, hormone, and second messenger changes.

Cells not only receive extracellular cues, they also translate them into intracellular reactions. Extracellular signaling molecules comprise growth factors, hormones, ions, neurotransmitters, or cytokines.


Cellular reaction time covers from a few seconds to several hours. Accordingly, responses must either be triggered and measured instantly, or they need to be observed in living cells over a longer period of time. BMG LABTECH microplate readers provide injectors and a high sampling rate if fast reactions need to be captured. Further, the Atmospheric Control Unit regulates CO2 and O2 levels inside the reading chamber to provide a feel-good atmosphere for long-term cell experiments.


Signaling events rarely come alone, they take place simultaneously or in concert. In order to clearly characterize signaling events, BMG LABTECH devices offer the possibility of reading several assays in just one well.

Resources

Search our Resources section for information about specific applications, literature citations, videos, blog articles and many other publications. Many of the resources provided are associated with current and previous instrument models and versions.

    • Neuroprotective mechanisms of ε-viniferin in a rotenone-induced cell model of Parkinson\'s disease: significance of SIRT3-mediated FOXO3 deacetylation

      Zhang, S;Ma, Y;Feng, J;[2020]

      Neural regeneration research

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    • Genetic parameters and associated genomic regions for global immunocompetence and other health-related traits in pigs

      Ballester, M;Ramayo-Caldas, Y;González-Rodríguez, O;Pascual, M;Reixach, J;Díaz, M;Blanc, F;López-Serrano, S;Tibau, J;Quintanilla, R;[2020]

      Sci Rep

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    • Siah2 integrates mitogenic and extracellular matrix signals linking neuronal progenitor ciliogenesis with germinal zone occupancy

      Ong, T;Trivedi, N;Wakefield, R;Frase, S;Solecki, DJ;[2020]

      Nat Commun

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    • CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury

      Ranek, MJ;Oeing, C;Sanchez-Hodge, R;Kokkonen-Simon, KM;Dillard, D;Aslam, MI;Rainer, PP;Mishra, S;Dunkerly-Eyring, B;Holewinski, RJ;Virus, C;Zhang, H;Mannion, MM;Agrawal, V;Hahn, V;Lee, DI;Sasaki, M;Van Eyk, JE;Willis, MS;Page, RC;Schisler, JC;Kass, DA;[2020]

      Nat Commun

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    • Protein kinase C eta is activated in reactive astrocytes of an Alzheimer\'s disease mouse model: Evidence for its immunoregulatory function in primary astrocytes

      Muraleedharan, A;Rotem-Dai, N;Strominger, I;Anto, NP;Isakov, N;Monsonego, A;Livneh, E;[2020]

      Glia

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