Signaling

No communication and cellular reactions without signaling molecules. Our microplate readers can characterize cytokine, hormone, and second messenger changes.

Cells not only receive extracellular cues, they also translate them into intracellular reactions. Extracellular signaling molecules comprise growth factors, hormones, ions, neurotransmitters, or cytokines.


Cellular reaction time covers from a few seconds to several hours. Accordingly, responses must either be triggered and measured instantly, or they need to be observed in living cells over a longer period of time. BMG LABTECH microplate readers provide injectors and a high sampling rate if fast reactions need to be captured. Further, the Atmospheric Control Unit regulates CO2 and O2 levels inside the reading chamber to provide a feel-good atmosphere for long-term cell experiments.


Signaling events rarely come alone, they take place simultaneously or in concert. In order to clearly characterize signaling events, BMG LABTECH devices offer the possibility of reading several assays in just one well.

Resources

Search our Resources section for information about specific applications, literature citations, videos, blog articles and many other publications. Many of the resources provided are associated with current and previous instrument models and versions.

    • The pore-forming subunit MCU of the mitochondrial Ca2+ uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice

      Georgiadou, E;Haythorne, E;Dickerson, MT;Lopez-Noriega, L;Pullen, TJ;da Silva Xavier, G;Davis, SPX;Martinez-Sanchez, A;Semplici, F;Rizzuto, R;McGinty, JA;French, PM;Cane, MC;Jacobson, DA;Leclerc, I;Rutter, GA;[2020]

      Diabetologia

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    • Exploring Biased Agonism at FPR1 as a Means to Encode Danger Sensing

      Gröper, J;König, GM;Kostenis, E;Gerke, V;Raabe, CA;Rescher, U;[2020]

      Cells

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    • Multimeric antibodies with increased valency surpassing functional affinity and potency thresholds using novel formats

      Miller, A;Carr, S;Rabbitts, T;Ali, H;[2020]

      MAbs

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    • The Na+/K+-ATPase is needed in glia of touch receptors for responses to touch in C. elegans

      Johnson, CK;Fernandez-Abascal, J;Wang, Y;Wang, L;Bianchi, L;[2020]

      J. Neurophysiol.

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    • Aggravated brain injury after neonatal hypoxic ischemia in microglia-depleted mice

      Tsuji, S;Di Martino, E;Mukai, T;Tsuji, S;Murakami, T;Harris, RA;Blomgren, K;Åden, U;[2020]

      J Neuroinflammation

      Read article