Aggregation of misfolded proteins leads to diseases like Parkinson’s, Alzheimer’s or prion disease. We have the dedicated reader for aggregation assays.
Methods that answer biochemical question are as varied as the chemical processes in living organisms. They cover simple protein quantification assays such as Bradford or Lowry assay to adjust protein extracts for further analysis, as well as enzyme activity assays helping to find inhibitory and accelerating conditions. These assays benefit from BMG LABTECH´s kinetic read options, an Enhanced Dynamic Range for high intensity variations in a measurement and a suite of enzyme kinetic analysis options.
An achievement of the past 20 years has been the multitude of protein interaction assays that can be carried out in 96 to 1536 well plates. They replace lengthy or radioactive procedures and facilitate the screening for potential active substances.
BMG LABTECH microplate readers measure all these assays. They not only provide highest sensitivity and throughput, if necessary, they further assist in developing your own assays and adapting existing methods to your specific target.
Search our Resources section for information about specific applications, literature citations, videos, blog articles and many other publications. Many of the resources provided are associated with current and previous instrument models and versions.
Fast and accurate detection of Alzheimer’s Disease targets with SimpleStep ELISA kits and SPECTROstar NanoMallori Milligan (1) , Scott Detmer (1) , Carl Peters (2), (1) Abcam, Cambridge, UK , (2) BMG LABTECH, Cary, NC, 08/2020
Immuno-oncology biomarker measurement with high sensitivity and speed using SimpleStep ELISA kits and SPECTROstar NanoMallori Milligan (1) , Scott Detmer (1) , Carl Peters (2), (1) Abcam, Cambridge, UK , (2) BMG LABTECH, Cary, NC, 06/2020
Binding kinetics: high throughput assay for kinase inhibitorsKrumm A (1) , Georgi V (2) , Schiele F (2) , Fernández-Montalván A (2), (1) BMG LABTECH GmbH , (2) Bayer AG, Drug Discovery, Pharmaceuticals, Berlin, Germany, 06/2020
Ubiquitination monitoring in real-time: the ﬂuorescence polarization-based method UbiRealTyler G. Franklin , Jonathan N. Pruneda, Oregon Health & Science University, Dept. of Molecular Microbiology and Immunology, Portland, OR, USA, 05/2020
Elucidating PROTAC MoA with live cell kinetic monitoring of ternary complex formation and target protein ubiquitinationKristin Riching , Amy Landreman , Danette Daniels, Promega, Madison, WI, U.S.A, 04/2020
Optimizing your ELISA Assays
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Protein measurement: find a suitable method
The absorbance spectrum of hemoglobin
Laccase and catecholoxidase activities contribute to innate immunity in slipper limpets, Crepidula fornicataRead article
Dev. Comp. Immunol.
ICOS signaling promotes a secondary humoral response after re-challenge with Plasmodium chabaudi chabaudi ASRead article
Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA SynthetaseRead article
ACS Infect Dis
Functional Role of N-Terminal Extension of Human AP Endonuclease 1 In Coordination of Base Excision DNA Repair via Protein-Protein InteractionsRead article
Int J Mol Sci
Systemic modified messenger RNA for replacement therapy in alpha 1-antitrypsin deficiencyRead article