Is there a fluorescence alternative to the hERG channel patch clamp assay?

September 24, 2012

The human ether-a-go-go related gene (hERG) potassium channel has been shown to be inhibited by certain drugs, which can cause cardiotoxic side effects such as long Q-T syndrome.

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Dr EJ Dell
PhD, Sales Manager Northwest

Therefore all new drugs have to be tested for interaction with the hERG channel. The classical way to test the hERG channel is with patch clamp studies, but this is time consuming and it requires specialized electrophysiological equipment.


Now there is a more cost-effective, faster alternative to the hERG patch clamp assay that is used to test drug-induced long Q-T syndrome. It is the Predictor® hERG cellular FP assay from Life Technologies. This fluorescence polarization application saves money and time by allowing potential drugs to be prescreened before undergoing more tedious patch clamp screening.


Find more information here: Application Note 173: Predictor™ hERG Fluorescence Polarization Assay Kit performed on the PHERAstar/PHERAstar Plus.

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