Learn which features help to easily resolve your binding events on a microplate reader.
G-protein coupled receptors are one of the best studied receptor families. Discover how plate readers can accelerate GPCR research, from signal transduction studies to high-throughput drug screenings.
G-protein coupled receptors (GPCRs) are one of the largest family of drug targets. Their activity is mediated by both G proteins and β-Arrestins which activate a network of distinct signalling pathways. GPCRs are involved in most cellular responses to hormones, metabolites, cytokines, and neurotransmitters, and are essential for intracellular communication. GPCRs are increasingly exploited in drug targets as their role is better understood in different signalling pathway and its central role in diseases such as Alzheimer's disease, cancer, and diabetes. Receptor binding, signalling, trafficking and other aspects of GPCR function can be studied to gain a better understanding of the response to a potential treatment. Explore the content below to understand how BMG LABTECH instruments can be utilised to study GPCRs and to screen potential drug targets using various read technologies of our readers.