G-protein coupled receptors are one of the best studied receptor families. Discover how plate readers can accelerate GPCR research, from signal transduction studies to high-throughput drug screenings. 

G-protein coupled receptors (GPCRs) are one of the largest family of drug targets. Their activity is mediated by both G proteins and β-Arrestins which activate a network of distinct signalling pathways. GPCRs are involved in most cellular responses to hormones, metabolites, cytokines, and neurotransmitters, and are essential for intracellular communication. GPCRs are increasingly exploited in drug targets as their role is better understood in different signalling pathway and its central role in diseases such as Alzheimer's disease, cancer, and diabetes. Receptor binding, signalling, trafficking and other aspects of GPCR function can be studied to gain a better understanding of the response to a potential treatment. Explore the content below to understand how BMG LABTECH instruments can be utilised to study GPCRs and to screen potential drug targets using various read technologies of our readers.
















    Kinase Assays
    September 01, 2020

    Kinase assays

    Kinases are a large and diverse group of enzymes which are the focus of roughly 1/3 of all drug development efforts due to their association with multiple diseases. Consequently, there is demand for assays that can detect kinase activity and subsequently their modulation by drug compounds. This has led to multiple commercial offerings that employ a variety of different detection technologies. Many of these assays employ microplates to allow for the measurement of 96 up to 1536 samples in parallel for which a multi-mode microplate reader is employed to read the experiment.

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    Calcium Assays
    July 03, 2020

    Calcium assays: at the centre of biology

    It is hard to consider life without calcium. Calcium ions play a central role in a huge variety of biological functions and cellular processes – from fertilisation, development and differentiation to metabolism, cell proliferation, secretion and muscle contraction, as well as brain functions including learning and memory1. This blog explains some of the many roles of calcium, and discusses the different ways that calcium ions can be measured. 

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