
Targeting a kinase? Find out how BMG LABTECH microplate readers measure interaction with kinases, kinase activities and kinase inhibitors in high throughput.
Drugs acting on a therapeutic target have to be identified out of libraries of thousands to millions of compounds. Due to the large amount of tests necessary for a screen, they are mainly conducted in 384 and 1536 well plates to minimize reaction volumes per sample.
Speed and sensitivity are key requirements for high-throughput screening microplate readers. A 1536 well microplate needs to be measured in seconds, maximally a few minutes. Furthermore, the fast measurement of 10 µl or even lower volume samples need to be very precise and stable to clearly identify hits from a vast number of compounds. In addition, the reader needs to be reliable, as errors occurring during a screen result in repetitions, loss of time, reagents and consequently money. The PHERAstar FSX masters all these requirements in all detection modes, making it popular in screening facilities.
For screening assay development and testing, it is not necessary to block the dedicated screening reader, the CLARIOstar Plus is the perfect addition to develop and characterize an assay before transitioning to high throughput.
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Cell Res
J Med Chem
Nat Commun
Front Physiol
Neuropsychopharmacology