Viruses are equally a threat to plants, bacteria, animals, and humans. They use their hosts to reproduce and can thereby damage them. This can lead, for example, to crop or farm animal losses and pandemics. On the other hand, viruses serve as tools for genetic engineering and the targeted modification of genomes.
Modern virology characterises viruses molecularly and functionally and uses this information to develop diagnostic tests, antiviral drugs and vaccines. Traditionally, virology largely relied on microscopic methods. Nowadays, microplate-based assays increase throughput and enable the measurement of replication, virus neutralization, binding of molecules to viral particles and much more.
Virus assays range from simple ELISA assays for measuring antibody titer to live-cell assays to measure replication. The variety of virus assays in combination with the need for cell-based methods requires a flexible microplate reader.
The CLARIOstar®Plus microplate reader offers this flexibility. It is a modular multi-mode reader that can be equipped with fluorescence, luminescence, absorbance and advanced detection modes. With its Atmospheric Control Unit, it is further optimized for live-cell assays as it creates the optimal environment for long-term cell-based experiments. The CLARIOstar Plus can be equipped with a red-shifted PMT for increased sensitivity with fluorophores emitting in the red range of light. These are often used in cell assays to avoid autofluorescence.
The PHERAstar FSX multi-mode microplate reader is the ideal platform for screening departments, where potential anti-viral compounds have to be detected quickly and efficiently in high throughput. In addition, it can quickly and effortlessly measure all FRET, TR-FRET and fluorescence polarization dual emission assays. These are often used in binding/interaction assays for anti-viral compound screens.
Browse our Resources section for information about specific applications, literature citations, videos, blog articles and many other publications. Many of the resources provided are associated with current and previous instrument models and versions.
FRET sensor assesses ATP levels in living plants experiencing low oxygen conditionsStephan Wagner (1,2) , Philippe Fuchs (1,2) , Thomas Nietzel (1,2) , Marlene Elsässer (1,2) , Markus Schwarzländer (1,2), (1) Institute of Plant Biology and Biotechnology, University of Münster, Germany , (2) Institute of Crop Science and Resource Conservation (INRES), University of Bonn, Germany, 02/2018
Transcreener ADP2 FI assay performed on BMG LABTECH microplate readersFranka Ganske (1) , Meera Kumar (2), (1) BMG LABTECH , (2) BellBrook Labs, 12/2014
Transcreener ADP2 FP assay certification for BMG LABTECH instrumentationMeera Kumar (1) , Franka Maurer (2) , EJ Dell (2), (1) BellBrook Labs , (2) BMG LABTECH, 12/2014
Lonza's PKLight protein kinase assay on the PHERAstar FS plate readerAndrew Paine , Lee Walker, Cambrex Bio Science (Lonza), 08/2005
Promega ENLITEN kit performed on a BMG LABTECH microplate readerRon Earp , Jarrett Cheek, BMG LABTECH, 05/2007
Neuroprotective mechanisms of ε-viniferin in a rotenone-induced cell model of Parkinson\'s disease: significance of SIRT3-mediated FOXO3 deacetylationRead article
Neural regeneration research
CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injuryRead article
EGFR-upregulated LIFR promotes SUCLG2-dependent castration resistance and neuroendocrine differentiation of prostate cancerRead article
Synergistic inhibitory effects of free nitrous acid and imidazoline derivative on metal corrosion in a simulated water injection systemRead article
A Low Dose of Nanoparticulate Silver Induces Mitochondrial Dysfunction and Autophagy in Adult Rat BrainRead article