Cell Signalling and its Therapeutic Implications

Friday, 24th of May 2021

Cells not only receive extracellular cues, they also translate them into intracellular reactions. Extracellular signaling molecules comprise growth factors, hormones, ions, neurotransmitters, or cytokines.


Cellular reaction time covers from a few seconds to several hours. Accordingly, responses must either be triggered and measured instantly, or they need to be observed in living cells over a longer period of time. BMG LABTECH microplate readers provide injectors and a high sampling rate if fast reactions need to be captured. Further, the Atmospheric Control Unit regulates CO2 and O2 levels inside the reading chamber to provide a feel-good atmosphere for long-term cell experiments.


Signaling events rarely come alone, they take place simultaneously or in concert. In order to clearly characterize signaling events, BMG LABTECH devices offer the possibility of reading several assays in just one well.

Resources

Search our Resources section for information about specific applications, literature citations, videos, blog articles and many other publications. Many of the resources provided are associated with current and previous instrument models and versions.

    • A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology

      Prabakaran, T;Troldborg, A;Kumpunya, S;Alee, I;Marinković, E;Windross, S;Nandakumar, R;Narita, R;Zhang, B;Carstensen, M;Vejvisithsakul, P;Marqvorsen, M;Iversen, M;Holm, C;Østergaard, L;Pedersen, F;Pisitkun, T;Behrendt, R;Pisitkun, P;Paludan, S;[2021]

      EBioMedicine

      Read article
    • Targeting alveolar-specific succinate dehydrogenase A attenuates pulmonary inflammation during acute lung injury

      Vohwinkel, CU;Coit, EJ;Burns, N;Elajaili, H;Hernandez-Saavedra, D;Yuan, X;Eckle, T;Nozik, E;Tuder, RM;Eltzschig, HK;[2021]

      FASEB journal : official publication of the Federation of American Societies for Experimental Biology

      Read article
    • INPP4B protects from metabolic syndrome and associated disorders

      Zhang, M;Ceyhan, Y;Kaftanovskaya, EM;Vasquez, JL;Vacher, J;Knop, FK;Nathanson, L;Agoulnik, AI;Ittmann, MM;Agoulnik, IU;[2021]

      Communications biology

      Read article
    • Pyrazole Agonist of the Apelin Receptor Improves Symptoms of Metabolic Syndrome in Mice

      Narayanan, S;Wang, S;Vasukuttan, V;Vyas Devambatla, RK;Dai, D;Jin, C;Snyder, R;Laudermilk, L;Runyon, SP;Maitra, R;[2021]

      Journal of medicinal chemistry

      Read article
    • Inducible mechanisms of disease tolerance provide an alternative strategy of acquired immunity to malaria

      Nahrendorf, W;Ivens, A;Spence, PJ;[2021]

      eLife

      Read article