Signaling

No communication and cellular reactions without signaling molecules. Our microplate readers can characterize cytokine, hormone, and second messenger changes.

Cells not only receive extracellular cues, they also translate them into intracellular reactions. Extracellular signaling molecules comprise growth factors, hormones, ions, neurotransmitters, or cytokines.


Cellular reaction time covers from a few seconds to several hours. Accordingly, responses must either be triggered and measured instantly, or they need to be observed in living cells over a longer period of time. BMG LABTECH microplate readers provide injectors and a high sampling rate if fast reactions need to be captured. Further, the Atmospheric Control Unit regulates CO2 and O2 levels inside the reading chamber to provide a feel-good atmosphere for long-term cell experiments.


Signaling events rarely come alone, they take place simultaneously or in concert. In order to clearly characterize signaling events, BMG LABTECH devices offer the possibility of reading several assays in just one well.

Resources

Search our Resources section for information about specific applications, literature citations, videos, blog articles and many other publications. Many of the resources provided are associated with current and previous instrument models and versions.

    • Doxorubicin generates senescent microglia that exhibit altered proteomes, higher levels of cytokine secretion, and a decreased ability to internalize amyloid β

      Marques, L;Johnson, AA;Stolzing, A;[2020]

      Exp. Cell Res.

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    • An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells

      Vinogradova, EV;Zhang, X;Remillard, D;Lazar, DC;Suciu, RM;Wang, Y;Bianco, G;Yamashita, Y;Crowley, VM;Schafroth, MA;Yokoyama, M;Konrad, DB;Lum, KM;Simon, GM;Kemper, EK;Lazear, MR;Yin, S;Blewett, MM;Dix, MM;Nguyen, N;Shokhirev, MN;Chin, EN;Lairson, LL;Melil[2020]

      Cell

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    • The Ca2+ channel CatSper is not activated by cAMP/PKA signaling but directly affected by chemicals used to probe the action of cAMP and PKA

      Wang, T;Young, S;Krenz, H;Tüttelmann, F;Röpke, A;Krallmann, C;Kliesch, S;Zeng, XH;Brenker, C;Strünker, T;[2020]

      J. Biol. Chem.

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    • Stress and behavioral correlates in the head-fixed method: stress measurements, habituation dynamics, locomotion, and motor-skill learning in mice

      Juczewski, K;Koussa, JA;Kesner, AJ;Lee, JO;Lovinger, DM;[2020]

      Sci Rep

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    • Time restricted feeding provides a viable alternative to alternate day fasting when evaluated in terms of redox homeostasis in rats

      Bhoumik, S;Kumar, R;Rizvi, SI;[2020]

      Arch Gerontol Geriatr

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