Signaling

No communication and cellular reactions without signaling molecules. Our microplate readers can characterize cytokine, hormone, and second messenger changes.

Cells not only receive extracellular cues, they also translate them into intracellular reactions. Extracellular signaling molecules comprise growth factors, hormones, ions, neurotransmitters, or cytokines.


Cellular reaction time covers from a few seconds to several hours. Accordingly, responses must either be triggered and measured instantly, or they need to be observed in living cells over a longer period of time. BMG LABTECH microplate readers provide injectors and a high sampling rate if fast reactions need to be captured. Further, the Atmospheric Control Unit regulates CO2 and O2 levels inside the reading chamber to provide a feel-good atmosphere for long-term cell experiments.


Signaling events rarely come alone, they take place simultaneously or in concert. In order to clearly characterize signaling events, BMG LABTECH devices offer the possibility of reading several assays in just one well.

Resources

Search our Resources section for information about specific applications, literature citations, videos, blog articles and many other publications. Many of the resources provided are associated with current and previous instrument models and versions.

    • Novel Interactions Involving the Mas Receptor Show Potential of the Renin-Angiotensin system in the Regulation of Microglia Activation: Altered Expression in Parkinsonism and Dyskinesia

      Rivas-Santisteban, R;Lillo, J;Muñoz, A;Rodríguez-Pérez, AI;Labandeira-García, JL;Navarro, G;Franco, R;[2021]

      Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

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    • CPT1C negatively regulates the endocannabinoid hydrolase ABHD6 depending on nutritional status

      Miralpeix, C;Reguera, AC;Fosch, A;Casas, M;Lillo, J;Navarro, G;Franco, R;Casas, J;Alexander, SPH;Casals, N;Rodríguez-Rodríguez, R;[2021]

      British journal of pharmacology

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    • Comparisons of neuroinflammation, microglial activation, and degeneration of the locus coeruleus-norepinephrine system in APP/PS1 and aging mice

      Cao, S;Fisher, DW;Rodriguez, G;Yu, T;Dong, H;[2021]

      Journal of neuroinflammation

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    • Identification of Key Receptor Residues Discriminating Human Chorionic Gonadotropin (hCG)- and Luteinizing Hormone (LH)-Specific Signaling

      Lazzaretti, C;Secco, V;Paradiso, E;Sperduti, S;Rutz, C;Kreuchwig, A;Krause, G;Simoni, M;Casarini, L;[2020]

      International journal of molecular sciences

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    • A Combination of BRD4 and HDAC3 Inhibitors Synergistically Suppresses Glioma Stem Cell Growth by Blocking GLI1/IL6/STAT3 Signaling Axis

      Wang, Q;Jia, S;Wang, D;Chen, X;Kalvakolanu, DV;Zheng, H;Wei, X;Wen, N;Liang, H;Guo, B;Zhang, L;[2020]

      Molecular cancer therapeutics

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