Measuring thousands of wells in minutes, as it is needed for compound screens, requires extremely fast and sensitive instrumentation. Read why BMG LABTECH plate readers are heavily used in screening laboratories.

Drugs acting on a therapeutic target have to be identified out of libraries of thousands to millions of compounds. Due to the large amount of tests necessary for a screen, they are mainly conducted in 384 and 1536 well plates to minimize reaction volumes per sample.

Speed and sensitivity are key requirements for high-throughput screening microplate readers. A 1536 well microplate needs to be measured in seconds, maximally a few minutes. Furthermore, the fast measurement of 10 µl or even lower volume samples need to be very precise and stable to clearly identify hits from a vast number of compounds. In addition, the reader needs to be reliable, as errors occurring during a screen result in repetitions, loss of time, reagents and consequently money. The PHERAstar FSX masters all these requirements in all detection modes, making it popular in screening facilities.

For screening assay development and testing, it is not necessary to block the dedicated screening reader, the CLARIOstar Plus is the perfect addition to develop and characterize an assay before transitioning to high throughput.


Search our Resources section for information about specific applications, literature citations, videos, blog articles and many other publications. Many of the resources provided are associated with current and previous instrument models and versions.

    • 8-Benzylaminoxanthine scaffold variations for selective ligands acting on adenosine A2A receptors. Design, synthesis and biological evaluation

      Załuski, M;Schabikowski, J;Jaśko, P;Bryła, A;Olejarz-Maciej, A;Kaleta, M;Głuch-Lutwin, M;Brockmann, A;Hinz, S;Zygmunt, M;Kuder, K;Latacz, G;Vielmuth, C;Müller, CE;Kieć-Kononowicz, K;[2020]

      Bioorg. Chem.

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    • Adenosine A2A and A3 Receptors Are Able to Interact with Each Other. A Further Piece in the Puzzle of Adenosine Receptor-Mediated Signaling

      Lillo, A;Martínez-Pinilla, E;Reyes-Resina, I;Navarro, G;Franco, R;[2020]

      Int J Mol Sci

      Read article
    • New Insights into Arrestin Recruitment to GPCRs

      Spillmann, M;Thurner, L;Romantini, N;Zimmermann, M;Meger, B;Behe, M;Waldhoer, M;Schertler, GFX;Berger, P;[2020]

      Int J Mol Sci

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    • The Anti-Cancer Drug Dabrafenib Is a Potent Activator of the Human Pregnane X Receptor

      Creusot, N;Gassiot, M;Alaterre, E;Chiavarina, B;Grimaldi, M;Boulahtouf, A;Toporova, L;Gerbal-Chaloin, S;Daujat-Chavanieu, M;Matheux, A;Rahmani, R;Gongora, C;Evrard, A;Pourquier, P;Balaguer, P;[2020]


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    • An allosteric modulator binds to a conformational hub in the β2 adrenergic receptor

      Liu, X;Kaindl, J;Korczynska, M;Stößel, A;Dengler, D;Stanek, M;Hübner, H;Clark, MJ;Mahoney, J;Matt, RA;Xu, X;Hirata, K;Shoichet, BK;Sunahara, RK;Kobilka, BK;Gmeiner, P;[2020]

      Nat. Chem. Biol.

      Read article