Molecular biology

Our microplate readers answer your questions on nucleic acids: concentration, interaction with other nucleic acids or proteins, single nucleotide polymorphisms and expression of genes.

Molecular biology deals with biomolecules, their structure, function, and interactions. Since the discovery and description of DNA in the 1950s, we came to understand how DNA gets first transcribed into RNA and then translated into proteins. We further understand that the genome is not the only basis for a cell’s behavior, differentiation, and pathology. Epigenetic regulation, transcription regulation and non-coding RNAs are just as important.


Today, microplate reader assays are well-established tools to answer the questions that are still open. Luminescent reporter assays study gene regulation, interaction assays examine binding of nucleic acids to proteins and enzyme activity assays report on activities of polymerases or helicases.

 

Genomics is a multidisciplinary and essential part of modern biology.  Next generation sequencing (NGS) and SNP-genotyping are popular tools. The field is also closely associated with transcription and translation, investigating proteins and expression levels, both to directly inform studies but also as part of analysis workflows such as NGS.
Microplate reader also take measurements in preparation for PCRs and sequencing. They quantify nucleic acids in high throughput (96-1536 wells) and determine their purity via absorbance spectra.

 

BMG LABTECH microplate readers offer solutions from simple quantification devices able to quantify DNA, RNA and protein efficiently and in high throughput, up to multi-functional devices suitable for all needs: reporter assays, binding assays, enzyme assays, no matter which detection mode.

Resources

Search our Resources section for information about specific applications, literature citations, videos, blog articles and many other publications. Many of the resources provided are associated with current and previous instrument models and versions.

    • VALORISATION OF BIOETHANOL PRODUCTION RESIDUES THROUGH ANAEROBIC DIGESTION: METHANE PRODUCTION AND MICROBIAL COMMUNITIES

      Magdalena, J;Greses, S;González-Fernández, C;[2021]

      Science of The Total Environment

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    • The nuclear envelope protein Net39 is essential for muscle nuclear integrity and chromatin organization

      Ramirez-Martinez, A;Zhang, Y;Chen, K;Kim, J;Cenik, BK;McAnally, JR;Cai, C;Shelton, JM;Huang, J;Brennan, A;Evers, BM;Mammen, PPA;Xu, L;Bassel-Duby, R;Liu, N;Olson, EN;[2021]

      Nature communications

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    • Tuning Cell Behavior on 3D Scaffolds Fabricated by Atmospheric Plasma-Assisted Additive Manufacturing

      Cámara-Torres, M;Sinha, R;Scopece, P;Neubert, T;Lachmann, K;Patelli, A;Mota, C;Moroni, L;[2021]

      ACS applied materials & interfaces

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    • Genome-wide association mapping of leaf rust and stripe rust resistance in wheat accessions using the 90K SNP array

      Zhang, P;Yan, X;Gebrewahid, TW;Zhou, Y;Yang, E;Xia, X;He, Z;Li, Z;Liu, D;[2021]

      TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik

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    • A Graded, Porous Composite of Natural Biopolymers and Octacalcium Phosphate Guides Osteochondral Differentiation of Stem Cells

      Amann, E;Amirall, A;Franco, AR;Poh, PSP;Sola Dueñas, FJ;Fuentes Estévez, G;Leonor, IB;Reis, RL;van Griensven, M;Balmayor, ER;[2021]

      Advanced healthcare materials

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