Aggregation of misfolded proteins leads to diseases like Parkinson’s, Alzheimer’s or prion disease. We have the dedicated reader for aggregation assays.
Methods that answer biochemical question are as varied as the chemical processes in living organisms. They cover simple protein quantification assays such as Bradford or Lowry assay to adjust protein extracts for further analysis, as well as enzyme activity assays helping to find inhibitory and accelerating conditions. These assays benefit from BMG LABTECH´s kinetic read options, an Enhanced Dynamic Range for high intensity variations in a measurement and a suite of enzyme kinetic analysis options.
An achievement of the past 20 years has been the multitude of protein interaction assays that can be carried out in 96 to 1536 well plates. They replace lengthy or radioactive procedures and facilitate the screening for potential active substances.
BMG LABTECH microplate readers measure all these assays. They not only provide highest sensitivity and throughput, if necessary, they further assist in developing your own assays and adapting existing methods to your specific target.
Search our Resources section for information about specific applications, literature citations, videos, blog articles and many other publications. Many of the resources provided are associated with current and previous instrument models and versions.
Pyruvate kinase inhibitor measurements and effortless data analysis using the MARS data analysis softwareMartin Mangold , , BMG LABTECH 77799 Ortenberg, Germany, 02/2022
Excellent assay performance of THUNDER™ TR-FRET cell-based cytokine assays performed on the PHERAstar FSXGeneviève Chatel , Mireille Caron , and Jaime Padros, BioAuxilium Research, Inc., Montreal, Canada, 10/2021
Analysis of ERK1/2, p38αβγ and STAT3 phosphorylation with the THUNDER™ TR-FRET cellular kinase immunoassaysGeneviève Chatel , Mireille Caron , Jaime Padros, Bioauxilium Research, Inc., Montreal, Canada, 08/2021
Development of a microplate-based, near-infrared fluorescent detection method for unbound bilirubinCarl Peters, BMG LABTECH, USA, 07/2021
Development of an AlphaLISA protein-protein interaction assay to screen for re-purposed drugs as targeted disruptorsQuinlin Hanson, , Kelli Wilson, , Min Shen, , Zina Itkin, , Richard Eastman, , Paul Shinn, , Matthew Hall , , NCATS, NIH, 03/2021
Neurodegenerative disease research
Optimizing your ELISA Assays
Monoclonal antibody drugs – a history of success and a bright future!
Protein measurement: find a suitable method
The effect of mAb and excipient cryoconcentration on long-term frozen storage stability - part 2: Aggregate formation and oxidationRead article
International journal of pharmaceutics: X
Identifying targets for increased biogas production through chemical and organic matter characterization of digestate from full-scale biogas plants: what remains and why?Read article
Biotechnology for Biofuels and Bioproducts
Wolframin deficiency is accompanied with metabolic inflexibility in rat striated musclesRead article
Biochemistry and biophysics reports
In vitro and in vivo preclinical venom inhibition assays identify metalloproteinase inhibiting drugs as potential future treatments for snakebite envenoming by Dispholidus typusRead article
Molecular insight into 2-phosphoglycolate activation of the phosphatase activity of bisphosphoglycerate mutaseRead article
Acta crystallographica. Section D, Structural biology